Chaga mushrooms - are commonly found on Birch and other trees in cold climates, and has been used in folk medicine in Russia and other North European countries for generations. Chaga draws nutrients from the tree on which it grows and extracts are typically derived from the inner layers of the bark. The active constituents are thought to be a combination of triterpenes, such as betulinic acid, sterols, and polysaccharides.
Chaga has demonstrated anticancer, antiviral, antiplatelet, anti-inflammatory, analgesic, immune stimulating properties in vitro, and hypoglycemic effects in mice. Chaga extract has inhibitory and proapoptotic effects against colon cancer and hepatoma cells. It also reduced toxicity associated with radiation and inhibited tumor cell growth in animal models. In some studies, Chaga demonstrates selective apoptosis in tumor cells with no effects on healthy cells.
Constituents of chaga mushroom extract may interact with anticoa...
Chaga has demonstrated anticancer, antiviral, antiplatelet, anti-inflammatory, analgesic, immune stimulating properties in vitro, and hypoglycemic effects in mice. Chaga extract has inhibitory and proapoptotic effects against colon cancer and hepatoma cells. It also reduced toxicity associated with radiation and inhibited tumor cell growth in animal models. In some studies, Chaga demonstrates selective apoptosis in tumor cells with no effects on healthy cells.
Constituents of chaga mushroom extract may interact with anticoa...
gulant and anti-diabetic drugs. Although chaga is an edible fungus, it is not commonly ingested due to its bitter nature, yet it can be found as a tea, or can be made into a tea by using the whole mushroom.
Mechanism of action- Chaga demonstrated hypoglycemic effects in mice with diabetes mellitus .
It’s anti-inflammatory and pain relieving properties are thought to be via inhibition of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
An extract of chaga reduced the oxidative stress in lymphocytes from patients with from inflammatory bowel disease .
Chaga also showed anti-mutagenic properties . A hot water extract of chaga exhibited inhibitory and proapoptotic actions against colon cancer cell proliferation via up-regulation of Bax and caspase-3 and down-regulation of Bcl-2. Aqueous extracts of chaga also inhibited growth of human hepatoma cells via arrest of the cell cycle in Go/G1 phase and inducing selective apoptosis .
The selectivity may also be a result of activation from a change in the pH of the tumor micro-environment.
Betulinic acid, a constituent of chaga, is cytotoxic and triggers apoptosis through a direct effect on the mitochondria of cancer cells.
Other apoptosis-inducing factors result in cleavage of caspases and nuclear fragmentation.
Like many medicinal mushrooms, chaga is rich in beta glucans which have immunomodulating activities. Beta glucans bind to Complement Receptor 3 (CR3) that allows the immune cells to recognize cancer cells as “non-self”.
For Tea: Dissolve one teaspoon of the dried mushroom in one cup of water.
Alcohol extract (1:5 tincture): Use 40-60 drops, two to three times per day.
Mechanism of action- Chaga demonstrated hypoglycemic effects in mice with diabetes mellitus .
It’s anti-inflammatory and pain relieving properties are thought to be via inhibition of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
An extract of chaga reduced the oxidative stress in lymphocytes from patients with from inflammatory bowel disease .
Chaga also showed anti-mutagenic properties . A hot water extract of chaga exhibited inhibitory and proapoptotic actions against colon cancer cell proliferation via up-regulation of Bax and caspase-3 and down-regulation of Bcl-2. Aqueous extracts of chaga also inhibited growth of human hepatoma cells via arrest of the cell cycle in Go/G1 phase and inducing selective apoptosis .
The selectivity may also be a result of activation from a change in the pH of the tumor micro-environment.
Betulinic acid, a constituent of chaga, is cytotoxic and triggers apoptosis through a direct effect on the mitochondria of cancer cells.
Other apoptosis-inducing factors result in cleavage of caspases and nuclear fragmentation.
Like many medicinal mushrooms, chaga is rich in beta glucans which have immunomodulating activities. Beta glucans bind to Complement Receptor 3 (CR3) that allows the immune cells to recognize cancer cells as “non-self”.
For Tea: Dissolve one teaspoon of the dried mushroom in one cup of water.
Alcohol extract (1:5 tincture): Use 40-60 drops, two to three times per day.
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